Custom Peptides
Cayman Chemical AlflutInIbmesylate 10mg
An inhibitor of mutant EGFRs; selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR; reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 NSCLC PDX mouse model at 10 and 30 mg/kg
Cayman Chemical Metanephrine 10mg
An inactive metabolite of epinephrine; urinary and plasma levels are increased in patients with pheochromocytoma
Cayman Chemical 3hydroxy9 10DImethoxypTRo 10mg
A flavonoid; inhibits PDGF-BB-induced proliferation of, and DNA synthesis in, A-10 vascular smooth muscle cells (IC50s = 10 and 1 µM, respectively)
Cayman Chemical 3Hydroxy4methyl2 5HthIo 10mg
A degradation product of cefaclor; formed under aqueous acidic conditions
Cayman Chemical 4-O-Methylresveratrol 10mg
A stilbene with diverse biological activities; inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 UG/ml, respectively); inhibits arachidonic acid- or collagen-induced rabbit platelet aggregation from 0.05-0.2 mM; scavenges free radicals in a TEAC assay; suppresses RANKL-induced osteoclastic differentiation of murine BMDMs; reduces LPS-induced bone loss in mice at 50 mg/kg
Cayman Chemical Pralatrexate 10mg
A DHFR inhibitor (Ki = 13.4 pM) and antifolate; inhibits growth of acute lymphocytic leukemia cells (IC50 = 0.04 μM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 μM, respectively), and SK-LC8 and SK-LC16 NSCLC cells (IC50s = 0.42 and 0.11 μM, respectively); increases median survival in vivo in an H9 T cell lymphoma mouse xenograft model
Cayman Chemical Isavuconazole 10mg
A broad-spectrum triazole antifungal agent; inhibits the growth of clinical isolates of A. fumigatus, A. terreus, A. flavus, and A. lentulus (MIC90s = 0.39, 0.39, 2, and 0.25 mg/L, respectively) as well as C. albicans, C. krusei, and C. parapsilosis (MIC50s = 0.03, 0.06, and 0.03 mg/L, respectively); inhibits the growth of C. neoformans and C. gattii clinical isolates (MIC90s = 0.032 and 0.125 mg/L, respectively)
Cayman Chemical MyrIstoylLcarnItInchLRI 10mg
A long-chain acylcarnitine; plasma levels are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease
Cayman Chemical 8-Iso ProstaglndIn F1a 10mg
8-iso PGF1α is an isoprostane that was first identified in human semen.{1181} It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF1α is present along with its 19-hydroxy congener at 5-10 UG/ml of seminal plasma.{1323}
Cayman Chemical 4 MethylnItrosamIno1 3py 10mg
A tobacco-specific nitrosamine carcinogen; metabolites induce DNA alkylation and methylation; increases the protein levels of DNMT1 in mouse bronchial epithelial cells within one day and increases hypermethylation of the tumor suppressor genes Chd13, Prdm2, and Runx3 in lung tissue at a single dose of 100 mg/kg; NNK induces adenomas and adenocarcinomas, which are present after 16 and 50 weeks, respectively, in mouse lung following a single dose of 10 µmol/animal; lifetime administration results in a 90% lung tumor incidence in rats at 63.5 mg/animal
Cayman Chemical Falurdn 10mg
A nucleoside analog with antiviral activity, inhibiting thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM)
Cayman Chemical JacarIc AcId 10mg
A conjugated PUFA that induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM); increases the production of ROS, leading to oxidative stress that contributes to cytotoxicity
Cayman Chemical CID-2011756 10mg
An inhibitor of all three PKD isoforms (IC50s = 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively); cell permeable, blocking the phosphorylation of PKD1 on Ser916 (an autocatalytic target) in LNCaP prostate cancer cells in response to phorbol esters (EC50 = 10 μM)
Cayman Chemical AOD-9604acetate 10mg
A synthetic lipolytic peptide; decreases body weight, epididymal adipose tissue mass, and brown adipose tissue weight in ob/ob mice at 250 UG/kg per day; enhances cartilage regeneration in a rabbit model of collagenase-induced knee osteoarthritis